Hedison starred in the 1958 movie The Fly.

Among his many more TV and movie credits, he appeared in the TV version of Irwin Allen's Voyage to the Bottom of the Sea, and played Spencer Harrison on the U.s. soap opera Another World from 1991 to 1996. He is besides notable when a lone actor to use played James Bond's CIA comrade Felix Leiter in two film (Live and Let Die and Licence to Kill).

Inside 2004, he debuted on The Young and the Restless as Arthur Hendricks.

Trivia
Around Licence to Kill, an early scene involved Felix Leiter jump to the church. the chute go for it was filmed by owning a double, but Hedison was filmed landing by existence tied to the crane & brought to the ground. Director John Glen asked the crane operator to speed the crane as much as allow Hedison to l& promptly, however it was done as well quickly and following of this, Hedison got a hitch for the rest of the film.